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Research Article 


Fragmented Adipose Tissue Graft for Reconstruction of Pelvic Bone Defects in Sheep: Histopathological Analysis

Omed Ikram Shihab, Othman Abubakir Omar.

Abstract
Background and objectives: Adipose tissue is a connective tissue that is a good reservoir for stem cells. In last two decades adipose tissue has been widely used in regenerative medicine. In addition the adipocyte has the ability to dedifferentiate into progenitor cell. The aim of study is to investigate the ability of fragmented adipose tissue to repair critical size defects in vivo.
Material and Methods: Forty eight critical size defects were created in pelvic bone of 4 sheeps (12 defects/sheep) bilaterally. While in control groups (C) the defects left empty, the test groups (T) were augmented by fragmented adipose tissue. The animals were sacrificed over periods of 1, 2, and 4 months. Histopathological studies were done for all the samples. SPSS version 25 was used to analyze the results.
Results: The histologic results in both groups showed insignificant differences in 1st month groups. The test groups in 2nd and 4th months showed significantly higher bone formation than the control groups with P value (0.0241 and 0.0078) respectively.
Conclusion: Adipose tissue graft can serve as a physical and biological scaffold in bone repair process with excellent osteogenic potentials due to the presence of adipocytes that have the ability to differentiate to bony tissue.

Key words: Adipose tissue, graft, osteogenesis, sheep


 
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Pubmed Style

Shihab OI, Omar OA. Fragmented Adipose Tissue Graft for Reconstruction of Pelvic Bone Defects in Sheep: Histopathological Analysis. doi:https://doi.org/10.31838/ejmcm.07.01.18


Web Style

Shihab OI, Omar OA. Fragmented Adipose Tissue Graft for Reconstruction of Pelvic Bone Defects in Sheep: Histopathological Analysis. http://www.ejmcm.com/?mno=130009 [Access: October 13, 2020]. doi:https://doi.org/10.31838/ejmcm.07.01.18


AMA (American Medical Association) Style

Shihab OI, Omar OA. Fragmented Adipose Tissue Graft for Reconstruction of Pelvic Bone Defects in Sheep: Histopathological Analysis. doi:https://doi.org/10.31838/ejmcm.07.01.18



Vancouver/ICMJE Style

Shihab OI, Omar OA. Fragmented Adipose Tissue Graft for Reconstruction of Pelvic Bone Defects in Sheep: Histopathological Analysis. doi:https://doi.org/10.31838/ejmcm.07.01.18



Harvard Style

Shihab, O. I. & Omar, . O. A. (2020) Fragmented Adipose Tissue Graft for Reconstruction of Pelvic Bone Defects in Sheep: Histopathological Analysis. doi:https://doi.org/10.31838/ejmcm.07.01.18



Turabian Style

Shihab, Omed Ikram, and Othman Abubakir Omar. 2020. Fragmented Adipose Tissue Graft for Reconstruction of Pelvic Bone Defects in Sheep: Histopathological Analysis. doi:https://doi.org/10.31838/ejmcm.07.01.18



Chicago Style

Shihab, Omed Ikram, and Othman Abubakir Omar. "Fragmented Adipose Tissue Graft for Reconstruction of Pelvic Bone Defects in Sheep: Histopathological Analysis." doi:https://doi.org/10.31838/ejmcm.07.01.18



MLA (The Modern Language Association) Style

Shihab, Omed Ikram, and Othman Abubakir Omar. "Fragmented Adipose Tissue Graft for Reconstruction of Pelvic Bone Defects in Sheep: Histopathological Analysis." doi:https://doi.org/10.31838/ejmcm.07.01.18



APA (American Psychological Association) Style

Shihab, O. I. & Omar, . O. A. (2020) Fragmented Adipose Tissue Graft for Reconstruction of Pelvic Bone Defects in Sheep: Histopathological Analysis. doi:https://doi.org/10.31838/ejmcm.07.01.18








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