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Research Article 


Association of IL-4 and IL-6 Gene Polymorphism with Pulmonary Tuberculosis

Nktel Faaz AL-Saad, Mohammed A.K Alsaadi, Ali Hmood Al-saadi.

Abstract
The case-control study was aimed to evaluate the effect of IL-4 and IL-6 gene polymorphism on susceptibility to pulmonary tuberculosis in patients in Babylon province and also measure the serum level of these cytokine in in sera of studied group. The genotype association of rs2243250 (C/C, C/T, T/T) were significant (P<0.05) with (46.7, 38.3, 15)% respectively for PTB cases and (36.7, 26.6, 36.7)% respectively for control group. Allele's frequency for patients and control for IL-4 (rs2243250) were also significant (P<0.05) and the C allele represent the risk allele for PTB patients with odd ratio (95% CI) of 1.93(1.15-3.24), while the T allele represent protective allele for control group 0.52 (0.31-0.87). The genotype association of rs1800796 (C/C, G/C, G/G) were significant (P<0.05) with (43.3, 38.3, 18.4)% respectively for PTB cases and (50, 15, 35)% respectively for control group, whereas, the allele's frequency for patients and control of IL-6 (rs1800796) were insignificant with (P>0.05). There was a significant difference in mean level of both IL-4 and IL-6 serum concentration between pTB patients and controls (P<0.01). Also, there were an insignificant effect of IL-4 (rs2243250) and IL-6 (rs1800796) gene polymorphism on the difference in serum level of both IL-4 and IL-6 respectively in studied groups (P>0.05).

Key words: IL-4, IL-6, rs2243250, rs1800796, MTB and ELISA.


 
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How to Cite this Article
Pubmed Style

AL-Saad NF, Alsaadi MA, Al-saadi AH. Association of IL-4 and IL-6 Gene Polymorphism with Pulmonary Tuberculosis. doi:https://doi.org/10.31838/ejmcm.07.02.11


Web Style

AL-Saad NF, Alsaadi MA, Al-saadi AH. Association of IL-4 and IL-6 Gene Polymorphism with Pulmonary Tuberculosis. http://www.ejmcm.com/?mno=130806 [Access: October 13, 2020]. doi:https://doi.org/10.31838/ejmcm.07.02.11


AMA (American Medical Association) Style

AL-Saad NF, Alsaadi MA, Al-saadi AH. Association of IL-4 and IL-6 Gene Polymorphism with Pulmonary Tuberculosis. doi:https://doi.org/10.31838/ejmcm.07.02.11



Vancouver/ICMJE Style

AL-Saad NF, Alsaadi MA, Al-saadi AH. Association of IL-4 and IL-6 Gene Polymorphism with Pulmonary Tuberculosis. doi:https://doi.org/10.31838/ejmcm.07.02.11



Harvard Style

AL-Saad, N. F., Alsaadi, . M. A. & Al-saadi, . A. H. (2020) Association of IL-4 and IL-6 Gene Polymorphism with Pulmonary Tuberculosis. doi:https://doi.org/10.31838/ejmcm.07.02.11



Turabian Style

AL-Saad, Nktel Faaz, Mohammed A.K Alsaadi, and Ali Hmood Al-saadi. 2020. Association of IL-4 and IL-6 Gene Polymorphism with Pulmonary Tuberculosis. doi:https://doi.org/10.31838/ejmcm.07.02.11



Chicago Style

AL-Saad, Nktel Faaz, Mohammed A.K Alsaadi, and Ali Hmood Al-saadi. "Association of IL-4 and IL-6 Gene Polymorphism with Pulmonary Tuberculosis." doi:https://doi.org/10.31838/ejmcm.07.02.11



MLA (The Modern Language Association) Style

AL-Saad, Nktel Faaz, Mohammed A.K Alsaadi, and Ali Hmood Al-saadi. "Association of IL-4 and IL-6 Gene Polymorphism with Pulmonary Tuberculosis." doi:https://doi.org/10.31838/ejmcm.07.02.11



APA (American Psychological Association) Style

AL-Saad, N. F., Alsaadi, . M. A. & Al-saadi, . A. H. (2020) Association of IL-4 and IL-6 Gene Polymorphism with Pulmonary Tuberculosis. doi:https://doi.org/10.31838/ejmcm.07.02.11








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