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Research Article 


May Intrauterine Granulocyte Colony Stimulating Factor Improve Clinical & Ongoing Pregnancy & Live Birth Rates in Unexplained Repeated Implantation Failure Patients? A Randomized Clinical Trial

Atousa Karimi, Sara Mokhtar, Mohammad Reza Sadeghi, Simin Zafardoust, Mina Ataei, Aboulzal Ghoodjani, Arash Mohazzab, Fataneh Nazari, Soheila Ansaripour.

Abstract
Introduction & Objective: To study whether intrauterine granulocyte colony stimulating factor (G-CSF) improves the rates of clinical and ongoing pregnancy and live birth rates in unexplained repeated implantation failure (RIF) patients on their new ICSI-ET program.
Study Design: In University affiliated, Avicenna specialized center for fertility and repeated miscarriages 93 consenting unexplained RIF patients with normal endometrium and without any history of malignancy or uncontrolled background disease were enrolled in a registered, computer generated randomized double blinded placebo-controlled clinical trial. Patients underwent intrauterine perfusion of G-CSF or Placebo before ET and were monitored to calculate the Clinical & ongoing pregnancy and live birth rates in each group.
Result: The mean age was 32.855.02 years in G-CSF and 33.574.63 years in placebo group. There were no differences in baseline characteristic of patients and the ICSI protocols in groups. clinical and ongoing pregnancy and live birth rates were 17%, 14.9% and 12.8% in G-CSF group and 21.4%, 17.4 %and 13 % in control group respectively and did not show any statistically significant difference between the two groups. No adverse side effect was seen in the study groups.
Conclusions: In the study, intrauterine G-CSF did not affect clinical and ongoing pregnancy and live birth rates There was a non- significant improvement in clinical and ongoing pregnancy rate and also a reduction in the first trimester abortion in G-CSF patients. Non-significant higher ongoing pregnancy and lower abortion rates in the G-CSF group may be due to limited sample size or low G-CSF dosage. So further multicenter studies with larger sample size or higher doses of G-CSF is recommended. Clinical Trial Registration Number: IRCT2013063011653N2.

Key words: G-CSF, Recurrent Implantation failure, Pregnancy rate, Randomized controlled trial.


 
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How to Cite this Article
Pubmed Style

Karimi A, Mokhtar S, Sadeghi MR, Zafardoust S, Ataei M, Ghoodjani A, Mohazzab A, Nazari F, Ansaripour S. May Intrauterine Granulocyte Colony Stimulating Factor Improve Clinical & Ongoing Pregnancy & Live Birth Rates in Unexplained Repeated Implantation Failure Patients? A Randomized Clinical Trial. doi:https://doi.org/10.31838/ejmcm.07.02.12


Web Style

Karimi A, Mokhtar S, Sadeghi MR, Zafardoust S, Ataei M, Ghoodjani A, Mohazzab A, Nazari F, Ansaripour S. May Intrauterine Granulocyte Colony Stimulating Factor Improve Clinical & Ongoing Pregnancy & Live Birth Rates in Unexplained Repeated Implantation Failure Patients? A Randomized Clinical Trial. http://www.ejmcm.com/?mno=130816 [Access: October 13, 2020]. doi:https://doi.org/10.31838/ejmcm.07.02.12


AMA (American Medical Association) Style

Karimi A, Mokhtar S, Sadeghi MR, Zafardoust S, Ataei M, Ghoodjani A, Mohazzab A, Nazari F, Ansaripour S. May Intrauterine Granulocyte Colony Stimulating Factor Improve Clinical & Ongoing Pregnancy & Live Birth Rates in Unexplained Repeated Implantation Failure Patients? A Randomized Clinical Trial. doi:https://doi.org/10.31838/ejmcm.07.02.12



Vancouver/ICMJE Style

Karimi A, Mokhtar S, Sadeghi MR, Zafardoust S, Ataei M, Ghoodjani A, Mohazzab A, Nazari F, Ansaripour S. May Intrauterine Granulocyte Colony Stimulating Factor Improve Clinical & Ongoing Pregnancy & Live Birth Rates in Unexplained Repeated Implantation Failure Patients? A Randomized Clinical Trial. doi:https://doi.org/10.31838/ejmcm.07.02.12



Harvard Style

Karimi, A., Mokhtar, . S., Sadeghi, . M. R., Zafardoust, . S., Ataei, . M., Ghoodjani, . A., Mohazzab, . A., Nazari, . F. & Ansaripour, . S. (2020) May Intrauterine Granulocyte Colony Stimulating Factor Improve Clinical & Ongoing Pregnancy & Live Birth Rates in Unexplained Repeated Implantation Failure Patients? A Randomized Clinical Trial. doi:https://doi.org/10.31838/ejmcm.07.02.12



Turabian Style

Karimi, Atousa, Sara Mokhtar, Mohammad Reza Sadeghi, Simin Zafardoust, Mina Ataei, Aboulzal Ghoodjani, Arash Mohazzab, Fataneh Nazari, and Soheila Ansaripour. 2020. May Intrauterine Granulocyte Colony Stimulating Factor Improve Clinical & Ongoing Pregnancy & Live Birth Rates in Unexplained Repeated Implantation Failure Patients? A Randomized Clinical Trial. doi:https://doi.org/10.31838/ejmcm.07.02.12



Chicago Style

Karimi, Atousa, Sara Mokhtar, Mohammad Reza Sadeghi, Simin Zafardoust, Mina Ataei, Aboulzal Ghoodjani, Arash Mohazzab, Fataneh Nazari, and Soheila Ansaripour. "May Intrauterine Granulocyte Colony Stimulating Factor Improve Clinical & Ongoing Pregnancy & Live Birth Rates in Unexplained Repeated Implantation Failure Patients? A Randomized Clinical Trial." doi:https://doi.org/10.31838/ejmcm.07.02.12



MLA (The Modern Language Association) Style

Karimi, Atousa, Sara Mokhtar, Mohammad Reza Sadeghi, Simin Zafardoust, Mina Ataei, Aboulzal Ghoodjani, Arash Mohazzab, Fataneh Nazari, and Soheila Ansaripour. "May Intrauterine Granulocyte Colony Stimulating Factor Improve Clinical & Ongoing Pregnancy & Live Birth Rates in Unexplained Repeated Implantation Failure Patients? A Randomized Clinical Trial." doi:https://doi.org/10.31838/ejmcm.07.02.12



APA (American Psychological Association) Style

Karimi, A., Mokhtar, . S., Sadeghi, . M. R., Zafardoust, . S., Ataei, . M., Ghoodjani, . A., Mohazzab, . A., Nazari, . F. & Ansaripour, . S. (2020) May Intrauterine Granulocyte Colony Stimulating Factor Improve Clinical & Ongoing Pregnancy & Live Birth Rates in Unexplained Repeated Implantation Failure Patients? A Randomized Clinical Trial. doi:https://doi.org/10.31838/ejmcm.07.02.12








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