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Research Article 


Features of the Metabolic Syndrome and Type 2 Diabetes Mellitus in Schizotypal Disorder

Oleg V. Ermilov, Andrey Yu. Tretyakov, Lyubov V. Romasenko, Nina I. Zhernakova, Elizaveta S. Rudycheva, Inna V. Tikhonova, Irina A. Misan.

Abstract
Objective: To describe the features and mechanisms of development of metabolic syndrome (MS), type 2 diabetes melitus (DM2) and intermediate states of glycemia in psychosis the occurrence of these disorders, the values of total cholesterol (TC), fractions of high density lipoproteins (HDL), very low density lipoproteins (VLDL), triglycerides (TG), values of atherogenic coefficient (AC), insulinemia, ะก-peptidemia, insulin resistance (IR) the level of glycated hemoglobin (HbA1c) in a sample of patients with schizophrenia and in mentally healthy individuals.
Materials and methods: The frequency of carbohydrate metabolism disorders (CMD) was studied. Fasting glycemia was determined, and in the presence of its violation, a glucose tolerance test was performed. MS components were studied in patients with DM2, plasma concentrations of TC, HDL, VLDL, TG, C-peptide (CP), insulin and HbA1c were determined in patients with DM2, AC values and IR indices were calculated using HOMA-IR and CARO criteria.
Results: CMD in schizophrenia are more common than among mentally healthy subjects, amounting to 13.1% (p=0.02), and the main condition here is a significant number of individuals with impaired fasting glycemia (IFG) and impaired glucose tolerance (IGT) among women (CMD p=0.01; IGT p<0.001; IFG p=0.03). A feature of psychiatric sampling is a decrease in HDL by 16.4% (p=0.03) and an increase in AC by 52% (p=0.02). Mentally ill men with MS are characterized by a significantly large value of AC (p=0.019), insulinemia (p=0.02), CP level (p=0.02), HOMA-IR (p=0.01) and CARO (p=0.04) values than in mentally ill patients with DM2 without MS. In comparison with the control, regardless of gender, the schizophrenic patients with DM2 have significantly lower values of insulin (p=0.03), C-peptidemia (p=0.04) and IR, according to the criteria of HOMA-IR (p=0.01) and CARO (p=0.03).

Key words: schizophrenia, metabolic syndrome, diabetes mellitus, dyslipidemia, insulin, insulin resistance, C-peptide, glycated hemoglobin.


 
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How to Cite this Article
Pubmed Style

Ermilov OV, Tretyakov AY, Romasenko LV, Zhernakova NI, Rudycheva ES, Tikhonova IV, Misan IA. Features of the Metabolic Syndrome and Type 2 Diabetes Mellitus in Schizotypal Disorder. doi:https://doi.org/10.31838/ejmcm.07.02.20


Web Style

Ermilov OV, Tretyakov AY, Romasenko LV, Zhernakova NI, Rudycheva ES, Tikhonova IV, Misan IA. Features of the Metabolic Syndrome and Type 2 Diabetes Mellitus in Schizotypal Disorder. http://www.ejmcm.com/?mno=131047 [Access: October 13, 2020]. doi:https://doi.org/10.31838/ejmcm.07.02.20


AMA (American Medical Association) Style

Ermilov OV, Tretyakov AY, Romasenko LV, Zhernakova NI, Rudycheva ES, Tikhonova IV, Misan IA. Features of the Metabolic Syndrome and Type 2 Diabetes Mellitus in Schizotypal Disorder. doi:https://doi.org/10.31838/ejmcm.07.02.20



Vancouver/ICMJE Style

Ermilov OV, Tretyakov AY, Romasenko LV, Zhernakova NI, Rudycheva ES, Tikhonova IV, Misan IA. Features of the Metabolic Syndrome and Type 2 Diabetes Mellitus in Schizotypal Disorder. doi:https://doi.org/10.31838/ejmcm.07.02.20



Harvard Style

Ermilov, O. V., Tretyakov, . A. Y., Romasenko, . L. V., Zhernakova, . N. I., Rudycheva, . E. S., Tikhonova, . I. V. & Misan, . I. A. (2020) Features of the Metabolic Syndrome and Type 2 Diabetes Mellitus in Schizotypal Disorder. doi:https://doi.org/10.31838/ejmcm.07.02.20



Turabian Style

Ermilov, Oleg V., Andrey Yu. Tretyakov, Lyubov V. Romasenko, Nina I. Zhernakova, Elizaveta S. Rudycheva, Inna V. Tikhonova, and Irina A. Misan. 2020. Features of the Metabolic Syndrome and Type 2 Diabetes Mellitus in Schizotypal Disorder. doi:https://doi.org/10.31838/ejmcm.07.02.20



Chicago Style

Ermilov, Oleg V., Andrey Yu. Tretyakov, Lyubov V. Romasenko, Nina I. Zhernakova, Elizaveta S. Rudycheva, Inna V. Tikhonova, and Irina A. Misan. "Features of the Metabolic Syndrome and Type 2 Diabetes Mellitus in Schizotypal Disorder." doi:https://doi.org/10.31838/ejmcm.07.02.20



MLA (The Modern Language Association) Style

Ermilov, Oleg V., Andrey Yu. Tretyakov, Lyubov V. Romasenko, Nina I. Zhernakova, Elizaveta S. Rudycheva, Inna V. Tikhonova, and Irina A. Misan. "Features of the Metabolic Syndrome and Type 2 Diabetes Mellitus in Schizotypal Disorder." doi:https://doi.org/10.31838/ejmcm.07.02.20



APA (American Psychological Association) Style

Ermilov, O. V., Tretyakov, . A. Y., Romasenko, . L. V., Zhernakova, . N. I., Rudycheva, . E. S., Tikhonova, . I. V. & Misan, . I. A. (2020) Features of the Metabolic Syndrome and Type 2 Diabetes Mellitus in Schizotypal Disorder. doi:https://doi.org/10.31838/ejmcm.07.02.20








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