The diffuse colonic polyposis regards as a precancerous condition, thus both in tumorous and in premalignant condition the only therapy is the total colectomy. In our case on a 62-year-old male begun medical checkup due to weakness, slimming and haematochezia. The blood test revealed that the patients CA 19-9 levels were significantly elevated. The colonoscopy found multiple polyposis in the whole large bowel, furthermore a sigma carcinoma with stenosis. During the surgery multiple and bilobar colorectal liver metastasis were verified, which were proposed with CT scan. Because of the obstruction, we made a palliative sigma resection. Then adjuvant FOLFIRI therapy started. After 6 period chemotherapy performed abdominal CT scan showed the progression in the liver process. Therefore second-line Erbitux þ FOLFIRI chemotherapy started. After 11 cycles performed restaging CT scan showed significant regression of the liver metastasis. During the control colonoscopy the previously showed multiple polyposis of the large bowel were not detected, the polyps unexpectedly vanished. Because of the sig- nificant regression of the liver metastasis suggested the lobectomy, but the oncoteam decided to continue chemotherapy sequence. After 1 year in the course of oncology care performed PET-CT scan showed progression in the liver metastasis particularly in the right lobe. The oncologyst started third- line Avastin þ FOLFOX chemotherapy, but the patient died 3 years after the diagnosis. In our opinion, the regression of the diffuse colonic polyposis of the patient was due to the biological therapy. The submitted case is a literary rarity, because there is no relevant data in the literature that describes the positive effect of the chemotherapy for colon polyps.