Introduction and objective: We have investigated the re- lationship of thyroid cancer (TC) and anthropometric factors in Pakistani population as this association remains to be controversial. Methods: A total of 172 TC patients admitted at Aga Khan University Hospital (AKUH) from 2000 to 2014 were included. Patient’s demographics, tumor subtypes, body weight, height, body mass index (BMI), body surface area (BSA) and body fat percentage (BF%) were calculated. Results and discussion: Out of 221 patients, 172 patients were included in this study. Mean age was 43 years 7 15.40. Among all subtypes of TC, papillary remains the most common (72.1%), fol- lowed by medullary (10.5%), follicular (7.6%) and others (9.9%). Excess BMI 423 kg/m2, BF%, BSA, weight and height were sig- nificantly associated with TC incidence in overall population (p- value o 0.01*). In women, BF% was found to be in obese range (mean 1⁄4 35.07% 7 7.6, p-value r 0.01*). In men, height 4 160 cm and weight 460 kg were positively associated with TC. No sig- nificant relation was seen between gender and BMI.