For thousands of years, plants and herbs have provided a plethora of food and medicinal benefits to humans. Numerous studies have found that indigenous people from tropical countries use various parts of the Sida acuta plant to treat a variety of health problems, including rheumatic affections, azoospermia, oligospermia, and spermatorrhea, leucorrhoea, wounds, sciatica, nervous and heart diseases, colds, cough, asthma, tuberculosis, and respiratory diseases, diseases of the blood, bil It has been scientifically studied for its numerous pharmacological profiles, which include antioxidant, antimicrobial and antibacterial activity, antimalarial activity, cardioprotection (anti-cholesterol), analgesic and anti-inflammatory activity, antipyretic activity, hepatoprotection, hypoglycemic activity (low blood sugar), insecticidal activity, and anticancer activity. Its diverse properties and applications in traditional medicine are attributed to the presence of bioactive constituents such as alkaloids, saponins, saponin derivatives, coumarins, steroids, tannins, phenolic compounds, cardiac glycosides, sesquiterpene, and flavonoids, which are all present in significant amounts in the plant extract. It is the goal of this review research to provide a comprehensive evaluation of the literature on the ethnomedicinal uses, phytochemical and pharmacological profiles, and toxicity of Sida acuta, as well as its ethnomedicinal applications.