Aim: To assess the effect of Platelet Rich Plasma (PRP) in non-healing ulcers. Material and methods: It was a hospital based prospective cross-sectional & observational study between July 2020 to June 2021, at Hind institute of medical sciences, Safedabad, Barabanki. The history and examination were done bedside. In cases where the condition of patients doesn’t warrant giving history, their relatives or attendants were interviewed. A predesigned pretested semi-structured questionnaire was filled by the interviewer. Data was entered in Microsoft Excel sheet. The study area was General Surgery, Orthopaedics& medicine department, of Hind Institute of Medical Sciences, Safedabad, Barabanki.Pus culture and sensitivity were sent then after cleaning the wound with normal saline and betadine solution, already centrifuged platelet rich plasma was injected subcutaneously inside, in the periphery of wound and spread over floor of ulcer then dress with non-absorbent dressing. 1st dressing was changed on the 3rd day of injection then dressing was changed on every 7th day.We evaluated the effect of 1 dose of platelet rich plasma injection efficacy in wound/ulcer healing & reduction in wound/ulcer size and follow-up by visual inspection