The major clinical manifestation is weakness which evolves more or less symmetrically over a period of several days to four weeks. Proximal as well as distal muscles are involved with lower extremities being involved earlier than the upper. Trunk, intercostal, neck muscles and cranial nerves are affected later. All adult patients, diagnosed as Guillain-Barre Syndrome, who strictly complied with the NINCDS criteria, admitted to medical college hospital were included in this study. This includes a retrospective study of four years and prospective study of one year. Ninety seven patients entered the study. In our study, 52 (53.6%) patients had cranial nerve involvement. 7th, 9th and 10th Cranial nerves and the nerves supplying ocular muscles, were commonly affected in the descending order given. Seventh nerve was involved in 32 (33%) patients and out of this 7 patients had unilateral involvement.