Hypertension is one of the leading cause of global burden of diseases and as it is a chronic condition with significant detrimental effects on the wide range of health outcomes, cost effective management of hypertension appears to be a great challenge for both developed as well as developing countries. Even though recently there have been lot of studies on pharmacoeconomics and outcome research in the field of hypertension globally, but the results cannot be exactly extrapolated to Indian scenario as the economic status and socioeconomic factors are different in India as compared to the countries. Hence a study was undertaken to evaluate the cost effective antihypertensive drugs in our hospital. An observational comparative study is planned on 100 patients attending the outpatient Department of General medicine with a follow up period of 6 months. Written informed consent is obtained from all the patients satisfying the inclusion criteria. Multitherapy was frequently prescribed (74%), out of that Atenolol with Amlong combination was most common (54%). Diabetes was the most common co-morbid condition (24%). Multitherapy was most frequently prescribed, and Amlodipine with Enalapril combination proved to be most cost effective therapy. HRQoL was not much different in all the treatment groups.