Background:To assess the statistically significant difference in the serum lipid profile levels in the psoriasis cases and healthy controls and to evaluate atherogenicity in psoriatic patients which is a risk factor for cardiovascular disease.Psoriasis is a common and recurrent proliferative inflammatory skin disease that has been influenced by abnormal plasma lipid metabolism, genetic, environmental, viral, immunological factors and with high frequency of cardiovascular morbidity and mortality. Biochemically Psoriasis leads to increased synthesis and degradation of nucleoproteins, it is also associated with changes in blood biochemistry. This study was done to establish the correlation of lipid profile in the psoriasis patients and also to evaluate the risk of atherogenicity in psoriatic patients which is a risk factor for cardiovascular disease. Blood samples were analysed for the following parameters in lipid profile, total cholesterol, LDL, HDL, Triglycerides. A significant relation was found with dyslipidemia and increased risk of atherogenicity in psoriasis disease and severity of diseases in which the risk factors and secondary causes of hyperlipidemia were excluded.