Online ISSN: 2515-8260

A study on side effects oral gabapentin versus oral pregabalin for orthopedic surgery under spinal anesthesia

Main Article Content

Dr. Rahul Bankapur, Dr. Preeti Lamba,Dr. Kushank Sharma

Abstract

Pregabalin is a structural analogue of gamma aminobutyric acid, substituted at the 3-position; this facilitates diffusion across the blood-brain barrier. Efficacy of pregabalin has been proven in neuropathic pain, incisional injury, inflammatory injury. Its mechanism of action is probably the same as gabapentin but it is more lipid soluble and has superior pharmacokinetic profile. Due to its sleep modulating effects, it has been used as an anxiolytic. Pregabalin increases stages III-IV sleep phases and also decreases awakening at night. Patients were counselled regarding the tablet used in preemptive analgesia its advantages and disadvantages, the purpose of its use, they were also explained regarding the follow up till 24hr and spinal anaesthesia procedure to be used in the study and consent was taken for the same. Ramsey sedation score of all the patients was score = 2. None of patients complained of dizziness in group A. Ramsey sedation score of all the patients was score = 2.2.85% (1 patient) complained of dizziness in group B.

Article Details