Background: Cardiovascular diseases are the largest cause of mortality, accounting for around half of all deaths resulting from non communicable Diseases. The prospective observational study conducted to evaluate drug utilization in cardiovascular disease. Materials & Methods: The study included a total of 400 patients admitted to intensive coronary care unit. All the medical prescriptions were collected, and the data was used to analyze the prescription pattern by prescribing indicators and individual drug use by Defined daily dose (DDD) measure. The data was collected and analyzed for counts and percentages. The mean and standard deviation was computed for continuous variables. Results: In the present study 400 records were assessed in which males were 60% and females were 40%. Ischemic Heart Disease (32.5%) was the most common cardiovascular disease in study population followed by Hypertension (30%). DDD was highest of Enalapril maleate i.e. 4.45. The average drugs per prescription during hospitalization were 4.20. Percentage number of drugs Prescribed by generic names was 72%. Percentage of Drugs Prescribed from National Essential Drug List was 87.5%. Conclusion: The study concluded that DDD was highest of Enalapril maleate. The average drugs per prescription during hospitalization were 4.20. Percentage number of drugs Prescribed by generic names was 72%. Percentage of Drugs Prescribed from National Essential Drug List was 87.5%