Globally, breast cancer is considered one of the most common types of cancer among women. The National Institute of Health in collaboration with the National Coalition for Cancer Survivorship defines cancer survivors as an individual from the time of cancer diagnosis, through the balance of his or her life. Cancer-related Fatigue (CRF) is described as the distressing side effects of cancer and its treatment associated with physical, mental, and emotional manifestations including generalized weakness, diminished concentration, or attention, decreased motivation or interest to engage in normal activities and emotional lability. There are several validated tools for measuring cancer-related fatigue. The search for the relevant journal was carried out referring through many databases: PubMed, PubMed Central, Cochrane, and PEDro and mainly focuses on the RCTs, clinical trials, and systemic reviews. There are varieties of physical therapy interventions that play a beneficial role in reducing Cancer-related Fatigue followed by improvement in the physical activities, functional status thereby enhancing the lifestyle & quality of life among breast cancer survivors. These interventional programs will only be effective if the patient strictly adheres and follow the pre-designed exercise protocols referring through many guidelines for an effective outcome. The purpose of this research is to identify various effective assessment and physiotherapeutic interventions according to evidence-based studies on cancer-related fatigue among breast cancer survivors.