Background: Airway management is the basic responsibility of each and every anaesthesiologist. The present study was undertaken to evaluate the relationship between Mentohyoid distance and Cormac-Lehane Grading in predicting difficult intubation. Materials and Methods: The present study was carried among 200 patients belonging to ASA I and II physical status undergoing elective surgery in IMS & SUM HOSPITAL. During pre-anaesthetic check-up, patients were examined and mentohyoid distance was measured. On the day of surgery after induction, during laryngoscopy Cormack-lehane grading was observed, time taken for laryngoscopy and intubation was noted. The results were statistically analysed using SPSS version 22 software. “A p-value of p < 0.05 was considered statistically significant and p-value of p<0.001 was considered highly significant”.