Background:Gastroduodenal diseases are perhaps the commonest diseases in adult population worldwide. The present study was conducted to assess histopathological spectrum of various gastroduodenal lesions. Materials & Methods:72 patients with upper GI symptoms referred for endoscopy of both genders were included. Gastric mucosal biopsies from body and antrum were also taken for detection of H. pylori. The biopsy specimens were put into a small labelled bottle containing 10% buffered formalin. The biopsies were then processed, cut into sections of 4 micrometer thickness and stained with Haematoxylin and Eosin (H&E) and modified Giemsa techniques.