Background:Head trauma is defined as any physical hit or blow towards the head, which may or may not lead to an injury of the underlying brain. We consider a traumatic brain injury (TBI) to be a possible consequence of the traumatic event towards the head. Severe trauma is responsible of more than 5 million deaths every year worldwide and this incidence is expected to increase in the coming decades. TBI is the most severe condition observed in trauma patients, given that nearly 33% of patients with TBI die in hospital and another 33% have poor neurological recovery. Prevention and treatment of intra-cranial hypertension (ICH) are the cornerstones of treatment for patients with TBI in intensive care units (ICUs), as uncontrolled ICH worsens brain damage and remains the most common cause of death after severe TBI.