Background:Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related death worldwide. The present study was conducted to assess usefulness of AFP as a tumor marker in cases of HCC. Materials & Methods:72 hepatocellular carcinoma patients of both genders were enrolled. 5 ml of venous blood was taken and level of AFP was measured. Results: Out of 72, males were 42 and females were 30. There were 30 HBV, 12 HCV, 10 HBV and HCV positive, 7 HBV and HCV negative, 5 AFB1 positive and 8 HBV and AFB1 positive. AFP positivity was seen in 18, 3, 8, 2, 3 and 4 respectively. The mean AFP titre level (ng/ml) was 504.2, 482.6, 572.4, 461.2, 476.2 and 224.7 respectively. The difference was significant (P< 0.05).