Background: Interstitial lung disease (ILD) affects a large proportion of people with systemic sclerosis (SSc). Objectives: The aim of this study was to identify the role of KL-6in patients with SSc. For this objective, we studied the association between the KL-6 level, computed tomography (CT) score, and pulmonary function tests in SSc patients. Methods. 32 SSc patients underwent chest HRCT scans, pulmonary function tests and serum KL-6measurement.We usedWarrick scoresto distinguish the severity and extent of ILD at HRCT.KL-6 were sampled and measured, by enzyme linked immunosorbent assay (ELISA). Results:A positive correlation was found between serum KL-6 levels and the Warrick score (r 0.871, P < 0.001). KL-6 levels inversely correlated to with forced vital capacity(FVC%) (r-0.72, P < 0.001) , forced expiratory volume in 1second(FEV1%) (r -0.571, P < 0.001) and diffusion capacity for carbon monoxide(DLCO%) (r -0.543, P < 0.001). Conclusion:KL-6 levels correlate with findings seen in HRCTs and PFTs, indicating that they serve to assess the severity of SSc-ILD.