Background:Breast cancer is a major worldwide health problem. Many radiologists recognize that there are increasing incidence of breast cancer in the past decade.Automated threedimensional (3D) breast ultrasound (ABUS) was developed for better diagnosis of architectural distortions. Aim of work:evaluation of validity of ABUS in cancer breast detection in addition toHand Held Ultrasound (HHUS). Subjects and methods:This prospective cross-sectional study was done at radiology department of Al Sheikh Zayed Aal Nahyan hospital and included105 female patients, aged >18 years old, presented with breast complaint or screening, they were referred from general surgery Department of Al Sheikh Zayed Aal Nahyan Hospital. They were evaluated by HHUS and ABUS individually. Each lesion was assigned an independent BIRADS score for each modality.diagnosis was confirmed by biopsy (56cases). Results:HHUS and ABUS showed good substantial agreement regarding lesions classification (benign or malignant) with kappa (κ) 0. 789.with diagnostic accuracy and sensitivity of ABUS were higher than that of HHUS as for ABUS were 97.1% and 100% respectively, while for HHUS were 90.5% and 90.7 % respectively. Conclusion:From our results ABUS may serve as an effective new screening tool in addition to HHUS