One of the most promising problems associated with the use of chemotherapeutic agents for cancer is cardiac toxicity. The root cause of multiple cardiac toxicity disorders such as left ventricular failure, pericarditis, myocarditis, myocardial ischemia, arrhythmias, thromboembolism, prolongation of QT and hypertension are the antineoplastic agents.Anthracyclines, alkylating agents, tyrosine kinase inhibitors, antimetabolites and HER2-directed therapy are some major medications that can induce cardiotoxicity. A detailed literature survey on different chemotherapeutic agents for cancer has been carried out.The present review and analysis address cardiovascular risks, potential mechanistic mechanisms of chemotherapy-induced cardiotoxicity and cardio-protective agents used in chemotherapy for the treatment of cancer.