Corona Virus or SARS-CoV-2 or Covid-19 virus has disrupted the world like nothing else humanity has seen. It has brought about an unprecedented health crises that we only heard about in books. Every country was found wanting in preparation to fight the attack. With no treatment in sight, the only solution scientists started working on was to make a vaccine to prevent infection. Vaccine development history shows at best 10 years in the making. In a rare worldwide cooperation of best minds of the world, this feat was achieved in 10 months. Humanity will never forget the year 2020 which brought a crises and the human spirit to find solution to it. The main objective of this study is to look at the scenario post vaccine discovery and approval. The disease being so contagious, has to be curbed by vaccinating the entire population. This is not an easy task as it involves mind boggling efforts on part of government authorities who are directly concerned with public health. For a vast and highly populated country, it is even more complicated. The study examines the major challenges in vaccinating the billion plus Indian population. Availability of skilled manpower, a weak healthcare infrastructure, delivery logistics, cost of the vaccine, and spread of misinformation are some of the most important challenges that have emerged out of this study.