Background: Tube thoracostomy is defined as insertion of a tube (chest tube) into the pleural cavity to drain air, blood, bile, pus, chyle or other fluids The present study was conducted to compare tube thoracostomy in triangle of safety versus outside the triangle of safety. Material and methods: This study was multiple centre prospective comparative study conducted in department of Surgery. A total of 69 patients were included in study, randomized into two groups, tube thoracostomy in safe triangle (n=35) and tube thoracostomy outside safe triangle (n=34). All cases were carefully worked up in terms of detailed history and clinical examination. Lab and imaging intervention included.