Introduction: The most common concern associated with TKR is post-operative pain for both the patient and the surgeon. It is associated with multiple adverse physical and psychological consequences, which hinder postoperative mobilisation, increase the incidence of post-operative complications and the overall outcome.A number of modalities have been recommended of which regional techniques are preferred. Current study aims to compare post-operative management of pain in patients undergoing Total Knee arthroplasty (TKA) with epidural analgesia versus femoral nerve block.