Background:Oral Lichen Planus is a chronic inflammatory mucocutaneous disease affecting the oral cavity, skin and nails. The present study compared curcumin alone and curcumin with prednisone in management of cases of oral lichen planus. Materials & Methods:The present study was conducted on 68 patients diagnosed clinically and histologically as oral lichen planus which were divided randomly into 2 groups of 34 each. In group I patients, Curenext oral gel was prescribed for topical application for 15 minutes, three times a day. In group II patients, a paste of crushed tablet of prednisone and curenext oral gel was prescribed for 15 minutes, three times a day. All patients were recalled after 10 days for 1st follow up and 20 days later for 2nd follow up and reticulation, erosion and pain on VAS were recorded. Results: The mean reticulation score at baseline in group I was 1.82, in group II was 1.80, on 10th day in group I was 1.60 and in group II was 1.14 and on 20th day in group I was 0.86 and in group II was 1.42. The difference was significant (P< 0.05). The mean erosion score at baseline in group I was 2.32, in group II was 2.30, on 10th day in group I was 1.95 and in group II was 1.45 and on 20th day in group I was 0.82 and in group II was 0.10. The difference was significant (P< 0.05). The mean VAS score at baseline in group I was 4.10, in group II was 3.94, on 10th day in group I was 3.24 and in group II was 1.92 and on 20th day in group I was 1.26 and in group II was 0.06. The difference was significant (P< 0.05). Conclusion:Authors found that combination of curcumin and prednisone proved to be effective as compared to curcumin alone in patients of oral lichen planus.