Cancer occurs due to uncontrolled division of abnormal cells. Cancer cells may penetrate adjacent tissues and spread through the blood or lymphatic systems to other parts of the body. The most common childhood cancers are leukemias and brain or central nervous system tumors, which together account for the majority of the new childhood cases of cancer. Childhood cancer treatments usually include chemotherapy, radiation therapy, immunotherapy, and/or surgery, which can cause adverse effects in oral cavity for both short and long term treatment process. The pedodontist plays an important role in the prevention, stabilisation and care of oral and dental problems that can have an impact on the health and wellbeing of the child during and after cancer treatment. This article explains the various oral care need to be taken to maintain a good health and oral hygiene in Pediatric cancer survivors.