Online ISSN: 2515-8260

DEVELOPMENT AND CHARACTERIZATION OF CONTROLLED RELEASE TABLET BEARING ANTI HYPERTENSIVE DRUG

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NIDHI SHARMA,PRANAV KUMAR UPADHYAY

Abstract

Propranolol hydrochloride is used to treat high blood pressure, thyrotoxicosis, capillary hemangiomas, performance anxiety, and essential tremors and used to prevent migraine headaches. In this investigation-controlled release tablet of Propranolol Hcl was prepared using different polymers such as xanthan gum, tragacanth, sodium carboxy-methylcellulose, HPMC K4M, Eudragit S100, ethyl cellulose by direct compression method. All the precompression and post compression parameters of designed formulations of F1-F8 were evaluated and found to be within permissible limits. The optimized formulation (F7) showed a maximum percentage of drug release (100%) within 6hrs when compared to other formulations. From the FT-IR study it was concluded that there were no possible drug and polymer interactions. The short-term stability studies were carried out at 40±2°C and 75±5% RH and confirmed no changes in the weight, hardness and friability. Based on study results it may be concluded that tablets prepared will emerge as eminent candidates in treatment of hypertension

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