Background Little known effectiveness of smartphone app exercise user in Indonesian nursing-students. It is necessary to explore the influence of interactive technologies on self-rated health or overall well-being. This study was evaluated an interactive smartphone-health app for nursing-students and the impact of a program building with psychosocial base on the increase of exercise efficacy to promote levels of physical activity (PA). Methods A pretest-posttest non-equivalent control design applied in 70 Indonesian nursing-students. A randomized assignment with a time-cluster technique used to avoid information contamination between groups. The web-based group received a social cognitive theorybased behavioral skill-building intervention by a web-based game with team competition for 10-week of a program. Outcome included level of PA, health outcomes, and selfefficacy. Multivariate ANCOVA and Chi-square test were adopted to test pre- and postoutcome effects. Results The main effects of the intervention on the number of steps/day, distance walked, calories consumption, duration, and systolic blood pressure were significant (p<0.05). The intervention group participants recorded more steps/day (p < 0.001, eta = 0.522), greater distances walked (p < 0.001, eta = 0.521), greater calories consumption (p < 0.001, eta = 0.419), longer durations (p < 0.001, eta = 0.217), lower systolic blood pressure (p < 0.05, eta = 0.103), and self-efficacy (p > 0.05, eta = 0.041) than the control group participants. Conclusion Web-based game combined with group competition programs could successfully increase PA among nursing-students.