Research objective: to assess the structure and dynamics of the IDA incidence in the Republic of Uzbekistan in the period from 2007 to 2019. Material and methods. The research was carried out at the Department of Hematology of the Bukhara branch of the Tashkent Medical Academy. The data of official statistical report, accounts and reports, informational and analytical materials collected from 2007 to 2019 were used during the analysis. Mainly, the analysis included the state of epidemiological situation in the Kashkadarya, Bukhara and Navoi regions, as well as separately the Republic of Karakalpakstan. The study was comprehensive, using descriptive and analytical epidemiological methods, retrospective epidemiological analysis, and medical statistics. Results and discussion. During the analysis it was established that in the Republic of Uzbekistan for the period from 2007 to 2019, there was a changing of the severity grade of IDA for public health according to the WHO recommendations from medium (prevalence 20.0–39.9%) to moderate (5.0-19.9%). In some regions, where in 2007 the IDA incidence ratio was severe (≥40%), changing to the medium grade was achieved during 12 years. Conclusion. The epidemiological analysis showed the significant regression of the IDA incidence ratio in the Republic of Uzbekistan in the period from 2007 to 2019. However, among adolescents the prevalence of the disease remained high, requiring the development of a new approach to the treatment and carrying out preventive measures. In addition, it was established that in some regions the incidence was much higher than in the country as whole, requiring a deeper study of pathology in the indicated region.