AIM: To asses and compare the histopathological parameters and biological markers like βcatenin, N- cadherinand Calbindin in medulloblastoma (MB) subtypes. MATERIAL and METHODS: This retrospective comparative study includes 54 formalin fixed paraffin embedded tumor tissue samplesbetween January 2003 and December 2010. MB was first examined using standard histological preparations.Subsequently, immunohistochemistry was performed using antibody against β- Catenin, N-cadherin and Calbindin.