The Large Scale Social Restrictions, implementation has been regulated in Government Regulation (PP No. 21 of 2020) signed by the President of the Republic of Indonesia and along with the Minister of Health of Republic of Indonesia's Regulation (Permenkes No. 9 of 2020) concerning Large-Scale Social Limitation Guidelines in the Context of the Handling of COVID-19. This is undoubtedly to overcome the problem of dissemination COVID-19. This research aimed to find out the lifestyle of the people in East Nusa Tenggara, Indonesia, during the emergency response phase of COVID-19. Methods of data collection were executed by filling out the lifestyle questionnaires that were previously prepared and uploaded in the Google Form toward the population aged over 16 years in East Nusa Tenggara, Indonesia. This research was conducted by a cross-sectional study method. According to the results of data analysis, about 191 respondents were involved in this study. Information about COVID-19 was mostly obtained from the internet or social media was 71.20%. Daily consumption of vegetables and fruit was 39.27%. Around 47.64% of respondents experienced a change of habit, such as sometimes do sunbathe, and 30.89% of respondents increased physical activity frequency more than three times a week. The 98.43% of East Nusa Tenggara society tended to wear masks outside of their house, and 85.34% always wash their hands using soap. The prevalence of daily fresh food consumption during this virus pandemic was 77.49%, and instant food products were 2.62% every day. Factors that changed during the Covid-19 virus pandemic were smoking, physical activity, consumption, washing hands, wearing masks, sunbathing, and processed foods consumption.