Online ISSN: 2515-8260

In India, alcohol consumption is correlated with impaired β-cell function independent of body mass index

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1Utkal Kishore Khadanga, 2Madhusmita Mishra

Abstract

Type 2 diabetes is linked to alcohol consumption. The link between alcohol consumption and β-cell function, on the other hand, is still unknown. The purpose of this study is to look at the link between them. 675 Indian men between the ages of 20 and 75 were enlisted. The participants were first categorised into four categories: never drinkers, abstainers, light drinkers (0.1-19.9 g/day), moderate drinkers (20.0-39.9 g/day), and heavy drinkers (≥40.0 g/day), and then into two subgroups based on their body mass index (BMI) (BMI< 25kg/m2 and BMI ≥25kg/m2 ). Confounders such as age, smoking status, BMI, waist circumference (WC), blood pressure, lipids, and blood uric acid were used to adapt the analysis process.Alcohol intake was linked to lower homeostasis model assessment of β-cell function (HOMA-β) scores when compared to never drinkers, regardless of BMI. In the BMI<25kg/m2 group, the homeostasis model assessment of insulin resistance (HOMA-IR) was strongly connected with alcohol consumption history, and in the BMI≥25kg/m2 group, it was significantly correlated with alcohol consumption. The findings imply that alcohol intake is linked to β-cell dysfunction in Indian community-dwelling men, regardless of BMI.

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