Background:Atrial fibrillation (AF) is commonly associated with overweight and obesity. Overweight populations have higher incidence, prevalence, severity, and progression of AF compared with their normal weight counterparts. Stable weight loss decreases AF burden and AF recurrence following treatment.Epicardial adipose tissue (EAT) is a small but very biologically active ectopic fat depot that surrounds the heart. Given its rapid metabolism, thermogenic capacity, unique transcriptome, secretory profile, and simply measurability, epicardial fat has drawn increasing attention among researchers attempting to elucidate its putative role in health and cardiovascular diseases.