Background: CRP measurement is quick, non-invasive, and risk-free that can be a useful diagnostic test for evaluating and categorizing the risk levels and also anticipating the morbidity of both mother and fetus. Aims: To identify the association between the level of C-Reactive protein (CRP) with preterm deliveries. Materials and methods: It is Hospital based Prospective Observational study done for a period of 2 Years in 95 pregnant women with gestational age between 24 weeks to 36 weeks+6days, who present to emergency /labor room with regular uterine contractions, at least four in 20 minutes or eight in 60 minutes in presence or absence of cervical changes.Patients were then followed up till 7 days for preterm delivery. Further categorization of subjects was done into 2 groups:Group 1: Those who delivered preterm within 7 days of admission.Group 2: Those who did not deliver within 7 days of admission.