Background: Neonatal sepsis is one of the commonest cause of neonatal mortality in the developing world accounting for 30 -50 percent of 5 million neonatal deaths per year. The incidence of neonatal sepsis varies from 1 to 4 per 1000 live births in developed countries. Objectives: Antibiotic sensitivity pattern of neonatal sepsis and to assess risk factors in neonatal sepsis. Methodology: Crosssectionalstudy, All neonates born in IGIMS, and admitted in NICU, IGIMS, Patna. Study duration of Eighteen Months. with clinically suspected neonatal septicemia were includedin the study irrespective of the gestational age. Conclusion: Neonatal sepsis was common in males, term and low birth weight babies. Most common organisms isolated were gram negative and were sensitive to carbapenems. Prevention of risk factors like PROM and prolonged labour in decreasing sepsis playsa major role.