Chronic inflammation is a common feature of CKD and is a major cause of its associated morbidity and mortality. Erythropoiesis is inhibited by several pro-inflammatory cytokines such as interleukin-1, tumor necrosis factor-alpha (TNF-α) and interferon gamma (IFN-γ).12 These cytokines are particularly involved in the inflammatory process as they are directly produced by macrophages (TNF-α, IL-1) or because their production by another cell is induced by a macrophage cytokine (IFN-γ). Several studies have shown that markers of inflammation are associated with a decreased response to erythropoietin. Out of these 52 patients, 12 patients couldn’t complete the study. 5 patients (2 in group A and 3 in group B) left the study in between due to some unknown causes and 7 patients (4 in group A and 3 in group B) expired during the study.So finally 40 patients (20 in each group) completed the study. In group A there was a slight decrease in systolic and diastolic blood pressure from baseline values of 153.5±12.06 and 92.3±6.06 mm of Hg to 150.4±12.62 and 89.2±5.36 mm of Hg at 3 months, but the decrease was not significant statistically (p >0.05). In group B also there was a slight decrease in systolic and diastolic blood pressure from baseline values of 156.2±8.72 and 92.4±6.31 mm of Hg to 149.1±18.20 and 93.6±4.75 mm of Hg at 3 months, but the decrease was not significant statistically (p >0.05).