Objectives: Arterial stiffness develops with age and is an independent risk factor for cardiovascular disease. The brachial ankle pulse wave velocity (baPWV) and serum osteoprotegerin (OPG) are two new physiological and biochemical measures used to assess arterial stiffness. We looked at how age affects physiological and biochemical measures of arterial stiffness. Materials and methods: It were a cross-sectional, observational study on 118 apparently healthy male and 114 female patients aged 30–>60 years who did not have any cardiovascular or peripheral vascular disease and were not on any antihypertensive or lipid-lowering medication. The following parameters were measured: brachial systolic blood pressure (bSBP), brachial diastolic blood pressure, central systolic blood pressure (cSBP), central diastolic blood pressure (cDBP), heart rate, augmentation index (AIx[percent]), and baPWV. The recorded data were used to calculate the mean arterial pressure (MAP), pulse pressure (PP), and PP ratio (PPR). Serum samples were analysed in order to determine the OPG level and lipid profile. The Kruskal–Wallis’s test was used to compare the differences between the parameters.A Spearman correlation analysis was used to see if there was any relationship between baPWV and other parameters. To identify the factors linked with baPWV, multiple linear regression analysis was used. P 0.05 was deemed statistically significant.