Background: Preeclampsia (PE) is a multisystem disorder that complicates 5%– 10% of pregnancies and constitutes a major source of morbidity and mortality worldwide. Primigravidae are high risk group for development of PE and are almost four times as likely to develop the disease with its adversematernal and fetal outcome. Our study aimed to evaluate the platelet indices and serum uric acid and their significance in prediction of preeclampsia and assessment of its severity. Patients and methods: this study was included 108 primigravida at gestatational age (24-28) weeks at the first visit and divided into: group (1): including 54 pregnant women with pregnancy induced hypertension (PIH) of varying severity; group (2): including 54 normotensive pregnant women. Full history taking, complete clinical examination and laboratory investigations including platelet indices (platelet count (PC), mean platelet volume (MPV), platelet distribution width (PDW) and serum uric acid was estimated. Results: Age was distributed as 27.07±3.44 and 27.0±3.45 respectively between Preeclampsia group and Control group without significant difference and GA at start of the study was 26.01±1.49 and 26.11±1.40 respectively with no significant difference. SBP and DBP were significantly higher among Preeclampsia group. There was no significant difference between cases or control. PLT was significantly higher among control at all times but MPV and PDW were significantly higher among cases at al times. Low APGAR1, preterm, CS delivery type and PPH were significantly associated with preeclampsia group. Conclusion: The estimation of platelet indices and serum uric acid can be considered as an early, economical and rapid procedure for assessment of Preeclampsia in pregnant women. Thus platelet indices can have a significant impact on maternal and perinatal outcome.