Background: Hypocalcaemia is a common complication following thyroid surgery, cause of which is multifactorial. The aim of this study was to identify risk factors for development of post-operative hypocalcaemia in cases of total thyroidectomy, near total thyroidectomy, and completion thyroidectomy with or without neck dissection. Materials and Methods: From 1st November 2020 to 31st October 2021, 40 consecutive patients undergoing total thyroidectomy, near-total, sub-total or completion thyroidectomy at Govt Medical College & Hospital, Suryapet were enrolled in this prospective study, longitudinal, cohort study. The primary endpoints were the occurrence of post-operative hypocalcaemia as by defined as a nadir corrected serum calcium less than 8.0 mg/dL or symptomatic hypocalcaemia