Aim: The aim of the study was to compare the prevalence of glucose intolerance in chronic HBV infection. Materials and Methods: It was a retrospective cohort study conducted in the Department of Medicine, Nalanda Medical College & Hospital, Patna, Bihar, India, during the period of one year. A total of 250 CHB-infected patients who either attended medicine out-patient department or admitted to medicine ward between October 2021 and March 2022 were studied. The diagnosis of CHB was based on the presence of hepatitis B surface antigen positivity for more than 6 months. In all the patients, fasting plasma glucose and postprandial plasma glucose samples were obtained. HbA1C, serum alanine aminotransferase, serum aspartate aminotransferase, and α-fetoprotein were done for all the patients. Hepatitis B e antigen status, HBV DNA, and genotype were determined by a commercially available assay. Fibroscan (transient elastography) is performed in all the patients.