Background:Appendicitis occurs most commonly between the ages of 10 and 20 years and it has a male-to-female ratio of 1.4:1. The present study assessed validation of RIPASA score in diagnosis of suspected cases of acute appendicitis. Materials & Methods:86 patients with right iliac fossa pain and suspected to have acute appendicitis of both genders were assessed. All were assessed using the RIPASA scoring system on the basis of clinical assessment and hospital protocol, histopathological correlation done with a score. A score of 7.5 was considered a cut-off value for high probability of acute appendicitis. Results: Out of 86 patients, males were 52 and females were 34. RIPASA score <5 was seen in 15, 5-7 in 20, 7.5- 11.5 in 38 and >12 in 13. Emergency appendectomy was performed on 62, positive HPE reports for appendectomy was seen in 54, negative HPE for appendectomy in 8, perforated appendix in 4 and wound sepsis in 7 cases. Conclusion: RIPASA score is a better, easy, safe, and non-invasive diagnostic method for diagnosis of acute appendicitis.