The concept of cytokine storm is increasing popularity with the introduction of immunotherapy in various diseases most notably in cancer therapy. So the basic knowledge about this topic has to be acquired by any health care professionals. Thus in this review article we dealt about the different cytokines associated with cytokine storm, its pathophysiology especially which is caused by influenza, SARS-Cov, dengue virus infections. We discussed about different grading system in relation to the syndrome associated with cytokine storm and management related to it.