ABSTRACT Skin types of diseases are most common among the globe, as people get skin disease due to inheritance, environmental factors. In many cases people ignore the impact of skin disease at the early stage. In the existing system, the skin disease are identified using biopsy process which is analyzed and medicinal prescribed manually by the physicians. To overcome this manual inspection and provide promising results in short period of time, we propose a hybrid approach combining computer vision and machine learning techniques. For this the input images would be microscopic images i.e histopathological from which features like color, shape and texture are extracted and given to convolutional neural network (CNN) for classification and disease identification. Our objective of the project is to detect the type of skin disease easily with accuracy and recommend the best and global medical suggestions. This paper proposes a skin disease detection method based on image processing and machine learning techniques. The patient provides an image of the infected area of the skin as an input to the prototype. Image processing techniques are performed on this image and feature values are extracted and the classifier model predicts the disease. The proposed system is highly beneficial in rural areas where access to dermatologists are limited. For this proposed system, we use Pycharm based python script for experimental results.