Background: prototypical developing country as far as H. pylori infection is concerned and more than 20 million Indians are estimated to suffer from peptic ulcerdisease. There is very limited data regarding its prevalence in our country. So this study aims to ascertain the prevalence of the H. pylori infection in the patients. Methodology: The study was conducted with both out patients and in-patients of All india institute of medical sciences, Patna. The study conducted wasa cross sectional prospective study, Study duration of two years. he upper gastro intestinal endoscopy was done with flexible, fibro-optic endoscope with patients in left lateral positions. Two endoscopic biopsy fragments were obtained from each patient from the antrum. One biopsy fragment was sent to histopathology.