Background:In this study, it was aimed to describe rates, etiological agents of the secondary infections and its effect on clinical outcomes among hospitalized patients with COVID-19. Materials and Methods: A prospective comparative analysis of the characteristics of patients with and without secondary infection was carried out among 75 hospitalized adult patients with a confirmed diagnosis of COVID- 19 via RT-PCR. Results: A total of 75 hospitalized patients with confirmed COVID-19 were analyzed. Among them 44(58.6%) patients were males and the mean age was 47±16 years. Among included patients, 30 (40.0%) had at least one microbiologically documented secondary infection and 45 (60%) had no secondary infection. Conclusion: Parameters like Higher levels of TC, NLR, APTT, ferritin and procalcitonin can help the clinician to predict that patients are likely to have secondary infection, and cannot be completely ruled out. Duration of stay in hospital and mortality rate was significantly higher in subjects with secondary infection compared to subjects without secondary infection