Background: Abnormal thyroid function tests are frequently observed in patients of chronic kidney disease. Kidneys plays a significant role in thyroid hormone metabolism by conversion of T4 to T3 (the active metabolite). Low plasma free T3 in ESRD is a marker of the inflammation and endothelial activation; and is known to predict all cause mortality. The present study was done look for the biochemical abnormalities of thyroid function tests in chronic kidney disease and to correlate the severity of CKD and alterations of thyroid indices