Aim: In light of the paucity of data on the bacteriological layout of AECOPD sufferer in our country, the current study examined the layout of sputum bacteria and antibiotic sensitivity in AECOPD hospitalized patients. Material and methods: It was a prospective observational study conducted among 45 AECOPD patients diagnosed according to GOLD guideline (2019) in the department of pulmonary medicine, TMMC & RC, Moradabad. Sputum sample was collected in the morning before any meal & patient should not use oral antiseptics. After inoculating the sample for 48 hours, inoculation culture plate with growth was identified on the basis of culture characteristics, gram staining and biochemical reaction according to standard guidelines.The antibiotic sensitivity of recovered isolates were determined by Kirby Bauer disc diffusion method.