Incontinence can cause serious complications such as skin damage in the perineum. Incontinence Associated Dermatitis (IAD) is skin damage caused by exposure to urine or faces. Health education is sometimes not optimal because of its inaccurate purpose and lack of patients' involvement and empowerment. Patient or nurse empowerment-based-health education or educational empowerment is a reciprocal relation between professional health care providers and patients in which patients develop their skill, knowledge, and self-confidence to determine the focus on health care. The study aimed to find out the effect of empowerment education on preventing the incident of IAD in immobility patients. The study was quasi-experimental with two groups pre-test and post-test. Thirty-six were sample divided into two groups (control and intervention) and collected by purposive sampling. Data were analyzed by using paired t-test and an independent ttest. The results showed that there was a difference between pre and post-intervention so that there was the effect of empowerment education on prevention of the incident of IAD in immobility patients.