In Organophosphorus poisoning raised serum amylase (hyperamylasemia) level is secondary to pancreatic injury because of parasympathetic overstimulation and hypersecretion. There have been studies showing that elevated serum amylase on admission day was related to the development of respiratory failure need for ventilatory support and increased mortality. Observation method of primary source of information in the department of general medicine. Secondary source of information from published articles, journals, books, case sheets, discharge summary, related websites are used in planning, developing, synopsis and during dissertation as supporting document. In our study, mean AMYLASE levels in mild poisoning is 114.23, in moderate it is 312.77 and in severe it is 774.66.