Distinguishing urosepsis from febrile urinary tract infections is critical in therapeutic decisionmaking to identify appropriate treatments to avoid sepsis-related organ failure. Accurate diagnosis takes time and is prone to false-positive outcomes. Furthermore, patient reactions to urosepsis are complex and variable. As a result, the goal of this study was to create a new, early diagnostic predictor that might distinguish between patients with urosepsis and those with febrile urinary tract infections by combining initial procalcitonin and albumin levels.A retrospective analysis of 200 patients with febrile urinary tract infections during an eighteenmonth period. The independent risk variables for distinguishing urosepsis from febrile urinary tract infection were identified using univariate and multivariate logistic models. To examine the prediction accuracy of the procalcitonin/albumin ratio, a receiver operating characteristic (ROC) curve analysis was performed. Procalcitonin/albumin ratios were greater in the urosepsis group than in the febrile urinary tract infection group [2.254 (0.978, 6.299) vs 0.021 (0.004, 0.095); P<.001].